2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14736
    Azilsartan medoxomil
    		Antagonist 99.07%
    Azilsartan medoxomil (TAK 491), a prodrug form of Azilsartan (HY-14914), is an orally active angiotensin II receptor type 1 antagonist. Azilsartan medoxomil can be used for the study of essential hypertension.
    Azilsartan medoxomil
  • HY-P0205
    Saralasin
    		Antagonist 99.46%
    Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
    Saralasin
  • HY-B0780
    Fimasartan
    		Antagonist 99.60%
    Fimasartan (BRA-657) is an orally effective angiotensin receptor AT1 non-peptide antagonist. Fimasartan has antihypertensive effects. Fimasartan improves neuroinflammation and brain injury mediated by NLRP3 inflammatome after intracerebral hemorrhage, and has neuroprotective effect. Fimasartan inhibits the expression of inducible nitric oxide synthase through the inactivation of NF-κB and activator protein-1.
    Fimasartan
  • HY-117743
    Eprosartan
    		Antagonist 99.87%
    Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
    Eprosartan
  • HY-15834A
    Eprosartan mesylate
    		Antagonist 99.95%
    Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively.
    Eprosartan mesylate
  • HY-P1415A
    Norleual TFA
    		Antagonist 99.93%
    Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.
    Norleual TFA
  • HY-A0250
    Tasosartan
    		Antagonist 99.32%
    Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist.
    Tasosartan
  • HY-135363
    Valsartan Ethyl Ester
    		Antagonist 99.70%
    Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.
    Valsartan Ethyl Ester
  • HY-12765S
    Losartan-d4 (carboxylic acid)
    		Antagonist 98.09%
    Losartan-d4 carboxylic acid (E-3174-d4) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
    Losartan-d<sub>4</sub> (carboxylic acid)
  • HY-P1656
    (D-Pro7)-Angiotensin I/II (1-7)
    		Antagonist 99.95%
    (D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a Ki of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension.
    (D-Pro7)-Angiotensin I/II (1-7)
  • HY-B0205S
    Candesartan-d4
    		Antagonist 98.85%
    Candesartan-d4 (CV-11974-d4) is the deuterium labeled Candesartan (HY-B0205). Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).
    Candesartan-d<sub>4</sub>
  • HY-19732
    BIBS 39
    		Antagonist 99.70%
    BIBS 39 is a non-peptide angiotensin II receptor antagonist with antihypertensive activity, with higher affinity for the AT1 receptor than for the AT2 receptor. BIBS 39 competitively blocks AT1-mediated vasoconstriction and pressor responses, and effectively inhibits the activity of the renin-angiotensin-aldosterone system. BIBS 39 reduces diastolic blood pressure and induces mild, transient reflex tachycardia, with no off-target functional activity on the norepinephrine, K+/Cl− or vasopressin pathways. BIBS 39 can be used in research related to hypertension and renal hypertension[1][2][3].
    BIBS 39
  • HY-114285
    L-161638
    		Antagonist 98.03%
    L-161638 is a potent, selective and orally active AT2 receptor antagonist. L-161638 can be used for the research of cardiovascular disease, such as hypertension.
    L-161638
  • HY-102093
    ZD 7155hydrochloride
    		Antagonist 99.88%
    ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
    ZD 7155hydrochloride
  • HY-W414915
    Valsartan methyl ester
    		Antagonist 99.39%
    Valsartan (CGP 48933) methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective and orally active angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.
    Valsartan methyl ester
  • HY-18204S2
    Valsartan-d8
    		Antagonist 99.90%
    Valsartan-d8 is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
    Valsartan-d<sub>8</sub>
  • HY-121767
    PD 123177
    		Antagonist 98.14%
    PD 123177 is a nonpeptide antagonist specific for angiotensin II (AII) subtype AT2 receptor in mammalian systems.
    PD 123177
  • HY-W098792
    Candesartan methyl ester
    		Antagonist 98.13%
    Candesartan methyl ester (compound 14) is an antagonist for angiotensin II (AII) receptor with an IC50 of 66 nM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models.
    Candesartan methyl ester
  • HY-14914S
    Azilsartan-d5
    		Antagonist 99.42%
    Azilsartan-d5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.
    Azilsartan-d<sub>5</sub>
  • HY-B0202S1
    Irbesartan-d6
    		Antagonist 98.71%
    Irbesartan-d6 is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
    Irbesartan-d<sub>6</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

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